Also tut Rusty es seinem Vater Clark (Chevy Chase) und seiner Mutter Ellen (Beverly D’Angelo) gleich und lädt die gesamte Familie ins Auto, um quer durchs Land nach Kalifornien zu fahren. Dabei dürfen auch Rustys Schwester Audrey (Leslie Mann) und deren Nachrichtensprecher-Ehemann Stone Crandall (Chris Hemsworth) nicht fehlen. Aber natürlich geht auf der Reise längst nicht alles glatt und ein etwas sonderlicher Wildwasser-Reiseführer (Charlie Day) ist bald das geringste Problem der lebenslustigen Familie Griswold. 
Flight Denver - Las Vegas (DEN - LAS) $57+ Flight Dallas - Las Vegas (DFW - LAS) $59+ Flight Oakland - Las Vegas (OAK - LAS) $63+ Flight San Francisco - Las Vegas (SFO - LAS) $67+ Flight Cleveland - Las Vegas (CLE - LAS) $71+ Flight Los Angeles - Las Vegas (LAX - LAS) $74+ Flight Chicago - Las Vegas (ORD - LAS) $75+ Flight Seattle - Las Vegas (SEA - LAS) $81+ Flight San José - Las Vegas (SJC - LAS) $87+ Flight Houston - Las Vegas (HOU - LAS) $91+ Flight Houston - Las Vegas (IAH - LAS) $91+ Flight Detroit - Las Vegas (DTW - LAS) $111+ Flight Atlanta - Las Vegas (ATL - LAS) $113+ Flight Minneapolis - Las Vegas (MSP - LAS) $113+ Flight Santa Ana - Las Vegas (SNA - LAS) $118+ Flight Philadelphia - Las Vegas (PHL - LAS) $135+ Flight Washington - Las Vegas (BWI - LAS) $138+ Flight Boston - Las Vegas (BOS - LAS) $143+ Flight Fort Lauderdale - Las Vegas (FLL - LAS) $150+ Flight Newark - Las Vegas (EWR - LAS) $150+ Flight New York - Las Vegas (LGA - LAS) $176+ Flight Washington - Las Vegas (DCA - LAS) $179+ Flight New York - Las Vegas (JFK - LAS) $213+ Flight Chicago - Las Vegas (MDW - LAS) $227+

Flight San Francisco - Los Angeles (SFO - LAX) $81+ Flight Oakland - Los Angeles (OAK - LAX) $83+ Flight San José - Los Angeles (SJC - LAX) $97+ Flight Dallas - Los Angeles (DFW - LAX) $101+ Flight Chicago - Los Angeles (ORD - LAX) $111+ Flight Houston - Los Angeles (HOU - LAX) $115+ Flight Denver - Los Angeles (DEN - LAX) $117+ Flight Seattle - Los Angeles (SEA - LAX) $117+ Flight Fort Lauderdale - Los Angeles (FLL - LAX) $120+ Flight Detroit - Los Angeles (DTW - LAX) $127+ Flight Washington - Los Angeles (BWI - LAX) $141+ Flight Minneapolis - Los Angeles (MSP - LAX) $145+ Flight Austin - Los Angeles (AUS - LAX) $148+ Flight Atlanta - Los Angeles (ATL - LAX) $157+ Flight Philadelphia - Los Angeles (PHL - LAX) $157+ Flight Boston - Los Angeles (BOS - LAX) $161+ Flight Orlando - Los Angeles (MCO - LAX) $173+ Flight Newark - Los Angeles (EWR - LAX) $175+ Flight New York - Los Angeles (LGA - LAX) $187+ Flight Washington - Los Angeles (DCA - LAX) $198+ Flight Washington - Los Angeles (IAD - LAX) $217+ Flight Charlotte - Los Angeles (CLT - LAX) $224+
Flight Orlando - Washington (MCO - DCA) $85+ Flight Boston - Washington (BOS - DCA) $131+ Flight New York - Washington (LGA - DCA) $147+ Flight New York - Washington (JFK - DCA) $147+ Flight Santa Ana - Washington (SNA - DCA) $156+ Flight Detroit - Washington (DTW - DCA) $157+ Flight Tampa - Washington (TPA - DCA) $157+ Flight Fort Lauderdale - Washington (FLL - DCA) $177+ Flight Chicago - Washington (ORD - DCA) $189+ Flight Minneapolis - Washington (MSP - DCA) $193+ Flight Atlanta - Washington (ATL - DCA) $201+ Flight Minneapolis - Washington (MSP - IAD) $201+ Flight Los Angeles - Washington (LAX - DCA) $202+ Flight Phoenix - Washington (PHX - DCA) $202+
Flight Chicago - New York (ORD - LGA) $93+ Flight Miami - New York (MIA - LGA) $99+ Flight Miami - New York (MIA - JFK) $101+ Flight Fort Lauderdale - Newark (FLL - EWR) $102+ Flight Atlanta - Newark (ATL - EWR) $103+ Flight Chicago - New York (ORD - JFK) $105+ Flight Dallas - New York (DFW - LGA) $113+ Flight Fort Lauderdale - New York (FLL - LGA) $113+ Flight Denver - New York (DEN - LGA) $126+ Flight Dallas - Newark (DFW - EWR) $151+ Flight Atlanta - New York (ATL - LGA) $157+ Flight Minneapolis - Newark (MSP - EWR) $161+ Flight Atlanta - New York (ATL - JFK) $169+ Flight Los Angeles - Newark (LAX - EWR) $175+ Flight Chicago - Newark (ORD - EWR) $181+ Flight Tampa - Newark (TPA - EWR) $182+ Flight Los Angeles - New York (LAX - LGA) $191+ Flight Minneapolis - New York (MSP - JFK) $193+ Flight Minneapolis - New York (MSP - LGA) $196+ Flight San José - New York (SJC - JFK) $197+ Flight Los Angeles - New York (LAX - JFK) $217+ Flight San Francisco - New York (SFO - JFK) $217+ Flight San Francisco - Newark (SFO - EWR) $231+ Flight San Francisco - New York (SFO - LGA) $238+
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